The new drug application (NDA) of the single dose adjuvant RSVPreF3 OA vaccine has been reviewed by the Ministry of Health, Labor and Welfare (MHLW) of Japan

Virus is a kind of submicroscopic particle that can be replicated by host cell system without complete cell structure. The virus does not have a cellular structure and cannot grow and replicate independently, but it can infect all living organisms with cells and has the characteristics of heredity and replication.

Hepatitis B vaccine is a special drug used to prevent hepatitis B. After vaccination, it can stimulate the immune system to produce protective antibodies, which exist in human body fluids. Once the hepatitis B virus appears, the antibody will act immediately to remove it, prevent infection, and will not harm the liver, so that the human body has the immunity to prevent hepatitis B, so as to achieve the purpose of preventing hepatitis B infection.

A large number of laboratory and clinical research data show that the immune response of HPV host plays a very important role in controlling HPV infection and related diseases. Low immune status to HPV is prevalent in patients with HPV precancerous lesions and cervical cancer. HPV preventive vaccine mainly uses synthetic L1 late protein virus like particles with natural spatial structure as the target antigen to induce the body to produce high titer serum neutralizing antibodies to neutralize the virus and assist tumor specific killing T lymphocytes to eliminate virus infection.

Nucleic acid vaccine is also called gene vaccine or DNA vaccine. Because nucleic acid vaccine does not need carrier and adjuvant when it is injected into muscle, it is also called naked nucleic acid vaccine. By intramuscular injection, this kind of vaccine can obtain more lasting antigen expression in muscle cells. This antigen can induce antibody production, T cell proliferation and cytokine release, especially the cytotoxic T cell (CTL) killing effect. The specific immune response mediated by cytotoxic T cells plays an important role in anti-tumor, anti-virus and elimination of intracellular parasitic infection. Among the numerous vaccines, nucleic acid vaccine has attracted much attention due to its unique advantages.