Vaccine development stage 3
Vaccine development stage 3
Since the 1970s, more than 40 kinds of infectious disease pathogens have been newly discovered in the world, such as HIV virus, highly pathogenic avian influenza H5N1 virus, SARS new coronavirus, mad cow prion virus, monkeypox virus, Lyme virus, Ebola virus, Legionella, O139 Vibrio cholerae, etc. At present, more than 30 HIV vaccines, including recombinant genetic engineering vaccines, nucleic acid vaccines and live attenuated vaccine vector vaccines, are undergoing clinical trials in various phases around the world; Some achievements have been made in the research of SARS virus inactivated vaccine; The human avian influenza vaccine has been applied for human trial. Many infectious diseases have no vaccine or are still in preclinical research stage.
With the development of immunology research, it is hoped that vaccines can cure diseases or prevent disease deterioration by inducing specific immune responses in infected individuals. Such vaccine products are therapeutic vaccines. Therapeutic vaccines currently under study:
For the treatment of tumor, the therapeutic effect of tumor vaccine is to use tumor antigen to carry out active immunity, stimulate the active specific immune response of the body to the tumor, so as to prevent the growth, diffusion and metastasis of the tumor;
For the treatment of cardiovascular diseases: the vaccine intervention in the immune process to prevent the occurrence and development of atherosclerosis (AS) has made encouraging progress.
For the treatment of hypertension: Switzerland's Cytos Biotechnology Company said that the preliminary results obtained from the phase IIa clinical trial showed that a vaccine CYT006-AngQb for the treatment of hypertension has a good clinical development prospect.
For the treatment of type I diabetes: there are 3 types of type 1 diabetes vaccines that have entered the clinical research stage published by FDA.
In short, vaccine research in the new era is in full swing. It is believed that there will be some vaccines on the market in the near future, adding more weapons and ammunition for human resistance to diseases.