Disposable, integrated and large-scale are the development trend of cell gene therapy production equipment and technology.
Disposable, integrated and large-scale are the development trend of cell gene therapy production equipment and technology.
Disposable production of viral vectors in the preparation of CGT drugs, different viral vectors require different quantities, and the production line needs to maintain its flexibility and lightweight, so disposable production equipment is particularly important. Disposable virus vector production equipment can flexibly change the production scale and virus types, and reduce pollution risks and cleaning requirements.
The integrated and decentralized production of cell preparation requires large-scale sterile production workshops, and the cost is high. The integrated cell preparation equipment can basically cover all steps with one equipment, which can effectively reduce the preparation cost. For example, the car-t cell preparation equipment clinimacs prodigy developed by meitianni, Germany, can integrate all functions including T cell separation, transduction, activation, enrichment and so on to realize the integration of cell preparation.
With the increasing demand for CGT drugs, the production demand for viral vectors has increased significantly. Virus vector is the bottleneck of CGT drug production, but it can realize large-scale production. Because of this, at present, more than half of gene therapy companies have developed the production method of virus vectors from traditional adherent culture to suspension culture.
The CFAM series cell factory automation equipment of Shenyang GREAT ELITES Intelligent Equipment Co., Ltd. is mainly used in biopharmaceutical cell multiplication culture, which can realize the automatic functions of infusion, liquid level leveling, drainage, cell digestion and vibration in the cell culture process. The equipment is suitable for the production enterprises that produce a large number of vaccines and stem cells.